Team news: Lazio were without Samuel Gigot, Danilo Cataldi, Nicolò Rovella and Matteo Cancellieri while Milan had to do without Zachary Athekame, Youssouf Fofana and Santiago Giménez. Kickoff time for the Coppa Italia Round of 16 was 21:00 CET at Stadio Olimpico.
Goal: Zaccagni (80′)
S.S. Lazio (4-3-3) – Maurizio Sarri
Christos Mandas; Adam Marušić, Mario Gila, Alessio Romagnoli, Luca Pellegrini (71′ Nuno Tavares); Mattéo Guendouzi, Matías Vecino (58′ Fisayo Dele-Bashiru), Toma Bašić; Gustav Isaksen (83′ Matteo Cancellieri), Taty Castellanos (58′ Tijjani Noslin), Mattia Zaccagni (83′ Pedro).
Unused: Furlanetto, Provedel; Lazzari, Patric, Provstgaard; Belahyane; Dia.
AC Milan (3-5-2) – Massimiliano Allegri
Mike Maignan; Fikayo Tomori, Koni De Winter, Strahinja Pavlović; Alexis Saelemaekers (64′ Christopher Nkunku), Samuele Ricci, Ardon Jashari (81′ Luka Modrić), Adrien Rabiot, Pervis Estupiñan (87′ Davide Bartesaghi); Ruben Loftus-Cheek (81′ Christian Pulisic), Rafael Leão.
Unused: Terracciano, Torriani; Gabbia, Odogu; Sala.
Referee: Marco Guida.